Drug resistance: evolution in action
Introduction of drugs puts an evolutionary pressure on viruses and makes the viral proteins evolve. On the other hand, the change in the protein structure should be compatible with the... Related...
View ArticleBeefing up the pipeline: new leads against influenza virus identified
Quantum Free energy calculation software in combination with the docking tools and clustering tools to “zip” the amount of work required to screen the large libraries of the available chemical......
View ArticleInfluenza matrix M1 protein inhibitors show promising in-vivo efficacy
We have recently reported a discovery of novel potent inhibitors of influenza M1 matrix protein. The matrix protein structurally forms the protein envelope and has no close human analogues. That’s......
View ArticleStructure-based drug design of a new chemical class of small molecules active...
The manuscript entitled “” by the Quantum Team has been accepted to PLoS Currents Influenza. The reference: Fedichev, Peter; Timakhov, Roman; Pyrkov, Tim; Getmantsev, Evgeny; Vinnik, Andrey....
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